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Genetics
Congress - Symposium -
E2
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E2
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The cell cycle, DNA replication
Back to the Symposium List
| Bellarine 1 - Wednesday 9th July 2003 - 10.00am - 12.00pm |
| Sponsor |
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| Convenor |
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Helena Richardson, Peter MacCallum Cancer Institute, Melbourne |
| Co-Convenor |
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Steve Reed, Scripps Research Institute, La Jolla, USA |
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| Speaker 1 | | Terry Orr-Weaver, Whitehead Institute, Cambridge, USA | | - Title of Presentation | | Developmental regulation of the cell cycle in Drosophila | | - Contributing Authors | | | | - Abstract | | Terry Orr-Weaver's research is at the interface of the fields of developmental biology and cell cycle regulation. She is studying how cell proliferation is coordinated with differentiation during the development of multicellular organisms, using Drosophila as a model. Organisms modify their cell cycles to achieve particular developmental goals, and Dr.Orr-Weaver's laboratory has defined regulatory mechanisms for these variant cell cycles. Using genetic and cell biological approaches they have identified a protein kinase complex that triggers mitosis in early embryogenesis, a centromere protein that promotes sister-chromatid cohesion, and a new component of the replication initiation complex. Dr. Orr-Weaver received her PhD from Harvard University in 1984 for research demonstrating that recombination is initiated by double-strand breaks. After postdoctoral research at the Department of Embryology of the Carnegie Institution of Washington in Baltimore, Maryland, she joined the Whitehead Institute and the Department of Biology at the Massachusetts Institute of Technology in 1987. She is a Member of the Whitehead Institute and a Professor of Biology at MIT. She has served on the Board of Directors of the Genetics Society of America and on several national grant review panels and editorial boards.
Two recent papers:
Claycomb, J., MacAlpine, D., Evans, J., Bell, S., and Orr-Weaver, T. (2002). Visualization of replication initiation and elongation in Drosophila. J.Cell Biol. 159, 225-236.
Bosco, G., Du, W., and Orr-Weaver, T. (2001). DNA replication control through interaction between E2F-RB and the Origin Recognition Complex.
Nature Cell Biol. 3, 289-295.
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| | Speaker 2 | | Steve Reed, Scripps Research Institute, La Jolla, USA | | - Title of Presentation | | The essential mitotic role of CKSl in S. cerevisiae is activation of CDC20 transcription | | - Contributing Authors | | | | - Abstract | | |
| | Speaker 3 | | Peter Sicinski, Dana Faber Cancer Institute, Boston, USA | | - Title of Presentation | | Cyclin E function in the mouse | | - Contributing Authors | | | | - Abstract | | |
| | Speaker 4 | | Jorg Heierhorst, St Vincent's Institute of Medical Research, Victoria, Australia | | - Title of Presentation | | A novel conserved protein family involved in cell cycle control and DNA damage responses in yeast and humans | | - Contributing Authors | | | | - Abstract | | |
| | Speaker 5 | | Sang Hoon Kim, Kyung Hee University, Seoul, Korea | | - Title of Presentation | | Sec13 regulates the transition of metaphase and anaphase in U2OS cells | | - Contributing Authors | | | | - Abstract | | |
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